Review of FDG-PET studies of memory impairment

FDGIn a paper to be published in a special issue of Neuropsychology Reviews, several members of the Inserm u1077 lab in Caen (including myself), give an overview of the 3-decade literature of FDG-PET studies of patients with memory deficits. The paper, which was led by Shail Segobin, a post doctoral fellow in the Inserm u1077 lab has three major sections:

  1. Fundamentals of PET‘, which explain the main principles of PET imaging: data acquisition and reconstruction, as well as partial volume effect and quantification issues. As a neuroimaging data specialist, Shail Segobin wrote this section, which could be a nice refresher for those who are not familiar with the underlying technique behind our nice 3D images!
  2. FDG-PET Investigations in non-Degenerative Pathologies‘. This section is an overview of FDG-PET findings is Alcohol-dependance, Korsakoff’s syndrome, transient amnesia, permanent organic amnesia and dissociative amnesia. Hélène Beaunieux, Anne-Lise Pitel, Ludivine Ritz, and Francis Eustache contributed to this section.
  3. FDG-PET Investigations in normal ageing and Neurodegenerative Diseases‘. Here, we described patterns of hypometabolism associated with ageing and associated neurodegenerative disorders, notably Alzheimer’s disease, but also dementia with Lewy body or Fronto-Temporal Dementias. Over and above simple description of FDG-PET abnormalities, we also summarized how they related to other brain alterations (atrophy or beta-amyloid deposition) or changes in cognition. This section was mainly contributed by Béatrice Desgranges, Gaël Chételat and I.

The review has several illustrations (including original figures, as well as 15 figures published in previous articles from our group and others) and above 200 references.

Segobin S, La Joie R, Ritz L, Beaunieux H, Desgranges B, Chételat G, Pitel AL, Eustache F (in press). FDG-PET contributions to the pathophysiology of memory impairment. NEUROPSYCHOLOGY REVIEWS
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About Renaud La Joie

PhD in neuroscience/neuropsychology. I am interested in age-related neurodegenerative diseases including Alzheimer’s disease & related disorders. My research involves multimodal neuroimaging and neuropsychological tools, as complementary approaches are required to better characterize - and hopefully understand - these disorders. From a more fundamental perspective, studying the diseased brain will also contribute to further our knowledge on the neural basis of cognitive functions in the normal brain.
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